When a user works on his XenDesktop-VDI and connects to a XenApp published app you may get some trouble when redirecting client drives.

By Default XenDesktop redirects the physical drive of your Thin/FatClient threw XenDesktop right into XenApp. Sometimes you may don´t want to use this – for example when using content redirection – and you have to map the real XenDesktop-Drives into XenApp.

To disable this feature you have to set the following regkey on your VDI:

HKEY LOCAL MACHINE\SOFTWARE

For x86: 
..\Citrix\ICA Client\Engine\Configuration\Advanced\Modules\ClientDrive
NativeDriveMapping:"True"

For x64: 
..\Wow6432Node\Citrix\ICA Client\Engine\Configuration\Advanced\Modules\ClientDrive
NativeDriveMapping:"True"